The story takes place in Manhattan during the height of the AIDS epidemic and revolves around the title character (Steven Weber), a gay man who has sworn off sex because of it. Almost immediately thereafter he meets Steve (Michael T. Weiss), a hunky, charming HIV positive man. He then experiences an emotional conflict as he must face his fear in order to accept love, often breaking the fourth wall to do so.
It's not so much that Jeffrey is afraid of dying himself, but that he's afraid that he will fall in love with someone who is bound to die; thus, his celibacy is not only about sex, but also about relationships in general. Helping him through this period of his life and advising him is a cast of cameos including Patrick Stewart, Nathan Lane, and Sigourney Weaver.